FebriDx
FebriDx Diagram
FebriDx® Instructions for Use
A DROP
OF FINGERSTICK BLOOD
AND 10 MINUTES
IS ALL YOU NEED.

Be sure to follow standard blood collection procedures for a fingerstick blood sample.

A DROP
OF FINGERSTICK BLOOD
AND 10 MINUTES
IS ALL YOU NEED.

Lance Finger

1Lance finger

Follow standard blood collection procedures for a fingerstick blood sample.

Twist and pull to remove the green protective lancet tab.

Firmly press the lancet to puncture the skin.

Wipe away the first drop of blood.

Collect Blood Sample

2Collect blood sample

Gently massage the finger to encourage blood flow to obtain a drop of blood that hangs from the finger.

Place the blood collection tube at a 45 degree angle, making contact with the hanging drop of blood. Avoid direct contact with the patient’s finger.

Fill the blood collection tube completely.

Gently squeeze the finger to add more blood if necessary. The blood collection tube must be full.

Deliver Blood Sample

3Deliver blood sample

Rotate the blood collection tube over the blood transfer zone allowing it to lock into position.

Wait for most of the blood to transfer to the blood transfer zone (~ 5-10 seconds).

If the blood does not immediately begin to transfer, reverse the blood collection tube back to its original position and ensure the tube is completely full before rotating back onto the blood transfer zone.

Deliver Buffer Solution

4Deliver buffer solution

Activate the test by firmly and fully pressing the buffer release button.

If no fluid is visible within 25-30 seconds, firmly re-press the buffer release button.

Place the test on a flat surface. Results will appear in the result window within 10 minutes.

Within 10 minutes, you will have reliable test results that you can use to make the most appropriate treatment and prescribing decisions. Colour-coded lines make interpretation of the results easy.

A blue control line must appear in the result window for the test to be valid.

bacterial infection
viral infection
negative result

Important Notes

Even if result line is faint in colour, incomplete over the width of the result window, or uneven in colour, it should be interpreted as positive.
If there is no blue control line, the test is invalid.
invalid results

Training Aids

What is the storage requirement of FebriDx®?
FebriDx® tests can be stored at room temperature (4-25°C or 39-77°F).
What patients should be tested with FebriDx®?

Patient with a new fever in the last 3 days

Patient with symptoms of a new ARI including: runny nose, nasal congestion, sore throat, new cough, hoarse voice, shortness of breath in the last 7 days

Patient that is 2 years or older

Patient not immunocompromised or taking chemotherapy, oral steroids, or interferon

Patient not taking antibiotics, antivirals, or had a recent live vaccine

Can FebriDx® be used on children?
Patients 2 years and older can be tested with FebriDx®.
What patient samples can be used on FebriDx® test?
Only fresh fingerstick blood can be used with the FebriDx® test. Venous whole blood cannot be used as MxA is an intracellular protein and once it is removed from the body, it loses stability.
When can the FebriDx® test results be interpreted?
FebriDx® test results can be read when 10 minutes have elapsed. FebriDx® test results are stable for up to one hour. Do not attempt to interpret results beyond one hour of test initiation.
The result line is faint. Does this affect the interpretation of results?
Even if the result line is faint in colour, incomplete over the width of the test strip, or uneven in colour, it should be interpreted as positive. A positive result indicates the presence of elevated MxA and/or CRP proteins.
The result line(s) is visible but the control line is absent. Can I still report the results?
A blue control line must appear in the result window for the test to be valid. The absence of the blue control line indicates an invalid result and the patient must be retested with a new FebriDx® test.
What is a clinically significant acute respiratory infection?
A “clinically significant” ARI is defined as the confirmation of a bacterial or viral pathogen in association with a host immune response. Unlike rapid antigen tests, PCR and culture, FebriDx® differentiates true infection from colonization/carriage through elevated levels of CRP/MxA.
Why do I sometimes see a CRP and an MxA line for some viral infections?
CRP is elevated in many viral infections including adenovirus and influenza. This is why CRP alone cannot differentiate between viral and bacterial infections. With FebriDx®, if the red line (MxA) is present then the result is a viral infection irrespective of CRP.
If you have further questions, please consult your FebriDx® User Guide or contact us at info@FebriDx.com